GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs11723261 | 1 | rs11723803 | chr4:292369 | ZNF718 | chr4:53272-156488:+ | 0.51 | 6.85 | 7.46E-10 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs11724176 | chr4:224901 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs11724417 | chr4:223352 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs11726829 | chr4:224948 | ZNF718 | chr4:53272-156488:+ | 0.54 | 6.17 | 1.69E-8 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs11729365 | chr4:272524 | ZNF718 | chr4:53272-156488:+ | 0.65 | 7.31 | 8.46E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs11730202 | chr4:210096 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs11723261 | 1 | rs11737268 | chr4:224452 | ZNF718 | chr4:53272-156488:+ | 0.54 | 6.17 | 1.69E-8 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs10461617 | 1 | rs11739344 | chr5:56111087 | C5orf35 | chr5:56205103-56213010:+ | 0.74 | 8.92 | 3.44E-14 | Type 2 diabetes |
| THYM | cis | rs1577917 | 1 | rs11758849 | chr6:86708262 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs11759855 | chr6:86610841 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs2066819 | 1 | rs117779516 | chr12:56750872 | RPS26 | chr12:56435686-56438005:+ | -0.92 | -4.35 | 3.48E-5 | Psoriasis vulgaris |
| THYM | cis | rs1875620 | 1 | rs11790735 | chr9:91563536 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1577917 | 1 | rs117907570 | chr6:86601283 | SNHG5 | chr6:86386726-86388451:- | -0.59 | -7.85 | 6.36E-12 | Response to antipsychotic treatment |
| THYM | cis | rs1875620 | 1 | rs11792354 | chr9:91563592 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1875620 | 1 | rs11792366 | chr9:91563653 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |